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Like other azole antifungalsclotrimazole exerts its effect by altering the fungal cell membraneClotrimazole inhibits ergosterol synthesis by interacting with 14-alpha demethylasea cytochrome P-450 enzyme that is necessary for converting lanosterol to ergosterolan essential component of the membraneIn contrastamphotericin B binds to ergosterol after it is synthesizedInhibition of ergosterol synthesis results in increased cellular permeabilitycausing leakage of cellular contents such as phosphorous-containing compounds and potassiumClotrimazole does not appear to have the same activity upon human cholesterol synthesisOther antifungal effects of azole compounds have been proposed and includeinhibition of endogenous respirationinteraction with membrane phospholipidsand inhibition of transformation of yeasts to mycelial formsAdditional mechanisms may involve inhibition of purine uptake . and impairment of triglyceride and/or phospholipid biosynthesisAs a treatment for infectious diarrheaclotrimazole is thought to interfere with chloride and resulting fluid accumulation in epithelial cells lining the intestine.

Sickle cell anemiasickle cell diseasea blood disease which shortens life expectancyis cause by an inherited abnormal.

Diflucanfluconazoleis a drug prescribed to treat fungal infections caused by Candidafor examplevaginaloralesophagealurinary tractpneumoniaand peritonitisSide effects include nauseadiarrheadizzinessrashindigestionand abdominal pain.

You are encouraged to report negative side effects of prescription drugs to the FDAVisit the FDA MedWatch website orcall 1-800-FDA-1088.

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