The dose of imuran required to prevent rejection and minimize toxicity will vary with individual patients, this necessitates careful management.
14DeWitte DBBuick MKCyran SEet alNeonatal pancytopenia and severe combined immunodeficiency associated with antenatal administration of azathioprine and prednisoneJ Pediatr1984105:625-628.
Particular care should be taken to monitor haematological response and to reduce the maintenance dosage , . to the minimum required for clinical response.
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Imuran may also be used with other disease-modifying therapiessuch as Avonexto boost their effect.
Xanthine oxidase activity is inhibited by allopurinoloxipurinol and thiopurinol which results in reduced conversion of biologically active 6-thioinosinic acid to biologically inactive 6-thiouric acidWhen allopurinoloxipurinol and/or thiopurinol are given concomitantly with 6-mercaptopurine or azathioprinethe dose of 6-mercaptopurine and azathioprine should be reduced to one-quarter of the original dose.
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