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Bupropion is used for the management of major depressionmajor depressive disorderand seasonal affective disorderdepression that occurs primarily during the fall and winterIt is also is prescribed for smoking cessationOff-label usesnon-FDA approvedfor bupropion include posttraumatic stress disorderPTSDanxietyattention deficit hyperactivity disorderADHDsocial phobiaand nerve painneuropathic pain

InitialUp to 3 mg/kg/day or 150 mg/day PO Titrate to 6 mg/kg/day or 300 mg/daymaximum.

Perform thorough cardiovascular assessment to identify risk factors . of sudden cardiac death in pediatric ADHD patients.

It may take 4 weeks or longer before you feel the full benefit of bupropionContinue to take bupropion even if you feel wellDo not stop taking bupropion without talking to your doctorYour doctor may decrease your dose gradually.

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a single dose study showed that the pharmacokinetics of bupropion and its metabolites in the elderly do not differ from those in the younger adults.