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Small CaltropsGokshurais helpful the management of uro-genital diseases like kidney stonesbladder infection and other urinary tract infectionsIt helps promote general urinary tract health by eliminating dysuriapainful urination or blood present in urineand crystalluriaSmall Caltrops prevents the depositionaccumulation and supersaturation of calculogenic chemicals in urineIt is a potent antimicrobial agent.

C Department of Laboratory Medicine and PathologyMayo ClinicRochesterMNUSA.

Many stone patients in Brazil take a tea made from the annual herb Phyllanthus niuri that grows in the tropical indigenous area and does not cause side effects12 This natural product has been calledbreak stonebecause it has been used for generations to eliminate gallstones and kidney stones12 Diverse classes of potentially active compounds have been identified from genus Phyllanthusincluding alkaloidsflavonoidslactonessteroidsterpenoidslignansand tanninsSome researchers have demonstrated antispasmodic and analgesic activities in Phyllanthus niuri which could explain the popular use of the plant for kidney and bladder stones12,13 The alkaloid extract caused smooth muscle relaxation specific to the urinary and biliary tract which could facilitate the expulsion of both kind of stones14 Phyllanthus niuri . has also been shown to inhibit CaOx endocytosis by renal tubular cells15 another mechanism by which this agent could decrease crystal retention in the kidneyand in a small clinical trial appeared to reduce urinary calcium excretion amongst hypercalciuric stone formers16 No toxicity was apparent in the latter studyA Moroccan herb Hernaria hirsuta has similarly been evaluated for effects on CaOx crystallizationincluding by our group17 InterestinglyPhyllanthus niuri is purported to act by promoting nucleation of more crystals that achieve a smaller size.

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Keywordsbacterial adhesionlipid peroxidationantioxidant enzymeshydrogen peroxideurinary tract infection.

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