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In the case of innopran xl, for example, we combined the active pharmaceutical ingredient, propranolol, with a proprietary drug release system licensed from eurand to produce the first night-time dosed beta blocker.

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For extended-release propranololInderal LAInnoPran XL and othersTake the missed dose as soon as you rememberSkip the missed dose if your next dose is less than 8 hours away.

HemangeolIndicated for treatment . of proliferating hemangioma requiring systemic therapy Initiate treatment at aged 5 weeks to 5 months Starting dose0.6 mg/kg0.15 mL/kgorally twice daily for 1 weekTHEN increase dose to 1.1 mg/kg0.3 mL/kgtwice dailyafter 2 more weeksincrease to maintenance dose of 1.7 mg/kg0.4 mL/kgtwice daily Administrationinfantile hemangiomasUse supplied oral dosing syringe for administration and give directly into the child’s mouthif necessarythe product may be diluted in a small quantity of milk or fruit juice and given in a baby’s bottle Administer doses at least 9 hours apart during or after feedings To reduce the risk of hypoglycemiaadminister during or right after a feedingskip the dose if the child is not eating or is vomiting Readjust dose periodically as the child’s weight increases Monitor HR and BP for 2 hours after initial dose and after increasing dose If hemangiomas recurtreatment may be reinitiated.

CommentsDose should be periodically adjusted as the weight of the child increasesAdministration directly into the mouth of the child is recommendedhoweverthe product may be diluted in a small quantity of milk or fruit juicegiven in a bottleThis drug should be administered during or right after a feeding to reduce the risk of hypoglycemiaThe dose should be skipped if the child is not eating or is vomitingHeart rate and blood pressure should be monitored for 2 hours after drug initiation or dose increasesIf hemangiomas recurtreatment may be reinitiated.

ChildrenImmediate release formulationsInitial0.5 to 1 mg/kg/day in divided doses every 6 to 12 hoursincrease gradually every 5 to 7 days Usual dose1 to 5 mg/kg/day Maximum dose8 mg/kg/day.

Tell your doctor and pharmacist if you are allergic to propranololany other medicationsor any ingredients in propranolol productsAsk your pharmacist or check the Medication Guide for a list of the ingredientstell your doctor and pharmacist what prescription and nonprescription medicationsvitaminsnutritional supplementsand herbal products you are taking or plan to takeBe sure to mention any of the followingACE inhibitorsantacids containing aluminumMaaloxMylantaothersanticoagulantsblood thinnerssuch as warfarinCoumadinJantovencalcium channel blockers such as diltiazemCardizemCartiaTiazacothersnicardipineCardenenifedipineAdalatProcardia XLand nisoldipineSularcholestyraminePrevalitecimetidineciprofloxacinCiprochlorpromazinecolestipolColestiddiazepamDiastatValiumdigoxinLanoxinfluvoxamineLuvoxhaloperidolHaldolHMG-CoA reductase inhibitorscholesterol-lowering agentssuch as lovastatinAltoprevMevacorin Advicorand pravastatinPravacholisoniazidin Rifamatein Rifatermedications for depression such as bupropionAplenzinForfivo XLWellbutrinZybanfluoxetineProzacSarafemSelfemraimipramineTofraniland paroxetineBrisdellePaxilPexevafluconazoleDiflucanmedications for migraine headaches such as rizatriptanMaxaltand zolmitriptanZomigmedications for high blood pressure such as clonidineCatapresKapvayin ClorpresdoxazosinCarduraprazosinMinipressand terazosinmedications for seizures such as phenytoinDilantinPhenytekand phenobarbitalcertain medications for irregular heartbeats such as amiodaroneCordaroneNexteronePaceronepropafenoneRythmoland quinidinein Nuedextamonoamine oxidaseMAOinhibitors such as phenelzineNardilmontelukastSingulairnonsteroidal anti-inflammatory drugsNSAIDssuch as indomethacinIndocinTivorbextheophyllineTheo-24TheochronUniphylreserpinerifampinRifadinRimactanein Rifaterin RifamateritonavirNorvirin Kaletrain Viekira PakteniposideVumonthioridazineticlopidinetolbutamidetricyclic antidepressantsand zileutonZyfloYour doctor may need to change the doses of your medications or monitor you carefully for side effectstell your doctor if you have or have ever had asthma or other lung diseaseheartliveror kidney diseasediabetessevere allergiesor thyroid problemstell your doctor if you are pregnantplan to become pregnantor are breast-feedingIf you become pregnant while taking propranololcall your doctorif you are having surgeryincluding dental surgerytell the doctor or dentist that you are taking propranololask your doctor about the safe use of alcoholic beverages while you are taking propranololAlcohol may increase the amount of propranolol in your bodytell your doctor if you use tobacco productsCigarette smoking may decrease the effectiveness of this medication.

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innopran xl extended-release capsules are supplied as capsules containing either 80 mg, or 120 mg of propranolol hydrochloride imprinted with innopran xl.