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Inform patients of the warning signs and symptoms of . hepatotoxicitye.gnauseafatiguelethargypruritusdiarrheajaundiceright upper quadrant tendernessandflu-likesymptomsIf these occurinstruct patients to stop Ponstel and seek immediate medical therapysee WARNINGSHepatotoxicity

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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofasthmableeding/clotting problemsblood disorderse.ganemiahigh blood pressurediabetesheart diseasee.ghistory of heart attackliver diseasegrowths in the nosenasal polypsobesitytobacco usehistory of stomach/intestine/esophagus problemse.gbleedingulcersrecurring heartburnstrokeswelling of the ankles/feet/hands.

No information is available from controlled clinical studies regarding the use of Ponstel in patients with advanced renal diseaseThe renal effects of Ponstel may hasten the progression of renal dysfunction in patients with pre-existing renal disease.

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i have been taking ponstel since 1999 and have found it is the only medication so far to relieve my pain during menstruation.