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Plasma . protein binding of ondansetron as measured in vitro was 70to 76over the concentration range of 10 to 500 ng/mLCirculating drug also distributes into erythrocytes.

ZOFRAN does not alter the respiratory depressant effects produced . by alfentanil or the degree of neuromuscular blockade produced by atracuriumInteractions with general or local anesthetics have not been studied.

Ondansetron hydrochloride dihydrate is a white to off-white powder that is soluble in water and normal saline.

For total body irradiation8 mg administered 1 to 2 hours before each fraction of radiotherapy each day.

Serotonin is produced largely in the gastrointestinal tractWhen a patient undergoes cancer treatmentradiation or chemotherapy drugs can cause specialized cells in the intestine to release serotoninZofran and the other 5-HT3 receptor antagonists work by preventing this serotonin from binding to 5-HT3 receptors.

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