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Have severe kidney problemsare allergic to capecitabine5-fluorouracilor any of the ingredients in XELODASee the end of this leaflet for a complete list of ingredients in XELODA.

Capecitabine is a type of chemotherapy called an anti metaboliteThe body changes capecitabine into a common chemotherapy drug called fluorouracilIt stops cells making and repairing DNACancer cells need to make and repair DNA so they can grow and multiply.

Capecitabine is a type of chemotherapy called an anti metaboliteThe body changes capecitabine into a common chemotherapy drug called fluorouracilIt stops cells making , . and repairing DNACancer cells need to make and repair DNA so they can grow and multiply.

In vitro enzymatic studies with human liver microsomes indicated that capecitabine and its metabolites5DFUR5DFCR5-FUand FBALdid not inhibit the metabolism of . test substrates by cytochrome P450 isoenzymes 1A22A63A42C192D6and 2E1.

In both trialsoverall survivaltime to progression and response ratecomplete plus partial responseswere assessedResponses were defined by the World Health Organization criteria and submitted to a blinded independent review committeeIRCDifferences in assessments between the . investigator and IRC were reconciled by the sponsorblinded to treatment armaccording to a specified algorithmSurvival was assessed based on a non-inferiority analysis.

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