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Avoid the use of FELDENE in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failureIf FELDENE is used in patients with severe heart failuremonitor patients for signs of worsening heart failure.

NSAIDsincluding piroxicamcan cause serious skin adverse reactions such as exfoliative dermatitisStevensJohnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of FELDENE at the first appearance of skin rash or any other sign of hypersensitivityFELDENE is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS

Concomitant use with other NSAIDsincluding COX-2 selective NSAIDs and acetylsalicylic acid at analgesic doses.

In a preand post-natal development study in which pregnant rats were administered , . piroxicam at 25or 10 mg/kg/day on Gestation Day 15 through delivery and weaning of offspringreduced weight gain and death were observed in dams at 10 mg/kg/day5 times the MRHD based on a mg/m 2 BSAstarting on Gestation Day 20Treated dams revealed peritonitisadhesionsgastric bleedinghemorrhagic enteritis and dead fetuses in uteroParturition was delayed and there was an increased incidence of stillbirth in all piroxicam-treated groupsat doses equivalent to the MRHDPostnatal development could not be reliably assessed due to the absence of maternal care secondary to severe maternal toxicity.

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