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Sulfamethoxazole, trimethoprim, smx-tmp, cotrimoxazole major because both trimethoprim and digoxin undergo tubular secretion, trimethoprim can interfere with the renal tubular secretion of digoxin when administered concomitantly.

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Heart failure patients with preserved ventricular function including acute cor pulmonaleamyloid heart diseaseand constrictive pericarditis may be susceptible to digoxin toxicity.

You should . not use this medication if you are allergic to digoxinor if you have ventricular fibrillationa heart rhythm disorder of the ventriclesor lower chambers of the heart that allow blood to flow out of the heart

Unsurprisinglythe UK media was vigorous in highlighting the potential dangers of digoxinHoweverthey did take the responsible step of advising readers not to stop taking digoxin without first consulting their GP.

To make sure you can safely take digoxintell your doctor if you have any of these other conditions:

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the lethal dose of digoxin is considered to be 20-50 times the maintenance dose taken at once.