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Induction of aminolevulinic acidALAsynthetaseand reduction in thyroid binding globulinT4with increased uptake of T3 but without disturbance of thyroid stimulating hormone or free thyroxin indexis also likely during therapy.

In humans2-hydroxymethylethisterone and ethisterone are the major urinary metabolites with unchanged danazol absentThe antigonadotrophic activity of danazol appears to be . exerted by the unchanged compound and not by one of its metabolitesfor the major metabolites are devoid of antigonadotrophic actionThe activity of danazol is slightly increased when it is administered with substances which inhibit the action of drug-metabolising enzymes.

Prolongation of prothrombin time occurs , . in patients stabilized on warfarinTherapy with Danazol may cause an increase in carbamazepine levels in patients taking both drugs.

Concomitant SteroidsAlthough specific instances have not been describedit is likely that interactionswill occur between danazol and gonadal steroid therapy.

Anti-Convulsant Therapydanazol may affect . the plasma level of carbamazepine andpossibly the patient’s response to this agent and to phenytoinWith phenobarbital it is likely that similar interaction would occur.

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nolvadex danocrine- danazol tablets are usually taken 1-2 times daily, swallowed whole without chewing, with some liquid during meals.