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Tineapityriasisversicolor is a non-contagious infection of the skin caused by Pityrosporum orbiculareMalassezia furfurThis commensal . organism is part of the normal skin floraIn susceptible individuals the condition is often recurrent and may give rise to hyperpigmented or hypopigmented patches on the trunk which may extend to the neckarms and upper thighsTreatment of the infection may not immediately result in restoration of pigment to the affected sitesNormalization of pigment following successful therapy is variable and may take monthsdepending on individual skin type and incidental skin exposureThe rate of recurrence of infection is variable.
In additiondystociadifficult laborwas noted in rats administered oral ketoconazole during the third trimester of gestationThis occurred when ketoconazole was administered at doses higher than 10 mg/kgabout one fourth the maximum human dosebased on body surface area comparison
Hepatobiliary Disordersserious hepatotoxicity including hepatitis cholestaticbiopsy-confirmed hepatic necrosiscirrhosishepatic failure including cases resulting in transplantation or death.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
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