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Avoid other hepatotoxicdermatotoxicQT-prolonging drugsIncreased ocular toxicity with concomitant tamoxifenMay potentiate digoxincyclosporinemonitorMay need to reduce dose of concomitant insulin or antidiabetic drugsIncreased seizure risk with other antimalarialsegmefloquineIncreased toxicity with methotrexateMay affect antiepileptics.

Periodic blood cell counts should be made if patients are given prolonged therapyIf any severe blood disorder appears which is not attributable to the disease under treatmentdiscontinuation of the drug should be consideredThe drug should be administered with caution in patients having G-6-PDglucose-6-phosphate dehydrogenasedeficiency.

Use this medication regularly in order to get the most benefit from itIf you are taking it on a daily scheduletake it at the same time each dayTake this medication exactly as prescribedDo not stop taking it withouttalking with your doctorespecially if you are taking it for malariaIt is important to continue taking this for the length of time prescribedStopping prevention or treatment too soon may lead to infection or a return of the infection.

Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bitesIt does not work against certain types of malariachloroquine-resistantThe United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the worldDiscuss the most recent information with your doctor before traveling to areas where malaria occurs.

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cases of cardiomyopathy resulting in cardiac failure, in some cases with fatal outcome, have been reported in patients treated with plaquenil see section 4.