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The use of celecoxib in patients 2 years to 17 years of age with pauciarticularpolyarticular course JRA or in patients with systemic onset JRA was studied in a 12-weekdouble-blindactive controlledpharmacokineticsafety and efficacy studywith a 12-week open-label extensionCelecoxib has not been studied in patients under the age of 2 yearsin patients with body weight less than 10 kg22 lbsand in patients with , . active systemic featuresPatients with systemic onset JRAwithout active systemic featuresappear to be at risk for the development of abnormal coagulation laboratory testsIn some patients with systemic onset JRAboth celecoxib and naproxen were associated with mild prolongation of activated partial thromboplastin timeAPTTbut not prothrombin timePTWhen NSAIDs including celecoxib are used in patients with systemic onset JRAmonitor patients for signs and symptoms of abnormal clotting or bleedingdue to the risk of disseminated intravascular coagulationPatients with systemic onset JRA should be monitored for the development of abnormal coagulation testsseeDOSAGE AND ADMINISTRATIONWARNINGS AND PRECAUTIONSADVERSE REACTIONSAnimal ToxicologyClinical Studies

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Inform patients not to use low-dose aspirin concomitantly with CELEBREX until they talk to their healthcare providersee DRUG INTERACTIONS

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long-term use of celebrex may cause renal kidney toxicity and decreased blood flow to the heart.