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For oral doses of conjugated equine estrogens0.625 mg the endometrial safety of added progestogens has not been demonstratedThe reduction in risk to the endometrium should be . weighed against the increase in the risk of breast cancer of added progestogenseeBreast Cancerbelow and section 4.8

In the WHI estrogen plus progestin substudya statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving daily CE0.625 mgplus MPA2.5 mgcompared to women in the same age group receiving placebo33 versus 25 per 10,000 women-yearssee Clinical StudiesThe increase in risk was demonstrated after the first year and persistedShould a stroke occur or be suspectedestrogen plus progestin therapy should be discontinued immediately.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

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if you are allergic to conjugated estrogens you should not take premarin.