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Large doses of estrogen5 mg conjugated estrogens per daycomparable to those used to treat cancer of the prostate . and breasthave been shown in a large prospective clinical trial in men to increase the risks of nonfatal myocardial infarctionpulmonary embolismand thrombophlebitis.
Long-term continuous administration of estrogenwith and without progestinin women with and , . without a uterushas shown an increased risk of endometrial cancerbreast cancerand ovarian cancerSee BOXED WARNINGSWARNINGS and PRECAUTIONS
18Grady DRubin SMPetiti DBet alHormone therapy to prevent disease and prolong life in postmenopausal womenAnn Intern Med 11719921016-36.
Suggested dosage is 10 mg three times daily for a period of at least three months.
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estrace is not appropriate for women who have a history of blood clots, stroke, heart attack, or undiagnosed vaginal bleeding.