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Iris color change may not be noticeable for several months to yearsTypicallythe brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownishNeither nevi nor freckles of the iris appear to be affected by treatmentWhile treatment with XALATAN can be continued in patients who develop noticeably increased iris pigmentationthese patients should be examined regularlysee PATIENT INFORMATION

Reduction of the IOP starts approximately 3 to 4 hours after administration and the maximum effect is reached after 8 to 12 hours.

You are encouraged to report negative side effects of prescription drugs to the FDAVisit the FDA MedWatch website or call 1-800-FDA-1088.

It is not known whether this drug or its metabolites are excreted in human milkBecause many drugs are excreted in human milkcaution should be exercised when XALATAN is administered to a nursing woman.

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