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Signs and symptoms of digoxin toxicity include anorexianauseavomitingvisual changes and cardiac arrhythmiasfirst-degreesecond-degreeWenckebachor third-degree heart blockincluding asystoleatrial tachycardia with blockAV dissociationaccelerated junctionalnodalrhythmunifocal or multiform ventricular premature contractionsespecially bigeminy or trigeminyventricular tachycardiaand ventricular fibrillationToxicity is usually associated with digoxin levels2ng/ml although symptoms may also occur at lower levelsLow body weightadvanced age or impaired renal functionhypokalemiahypercalcemiaor hypomagnesemia may predispose to digoxin toxicityObtain serum digoxin levels in patients with signs or symptoms of digoxin therapy and interrupt or adjust dose if necessarysee ADVERSE REACTIONS and OVERDOSAGEAssess serum electrolytes and renal function periodically.

A very serious allergic reaction to this drug is rareHoweverseek immediate medical attention if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere . dizzinesstrouble breathing.

The Patient Information LeafletPILis the leaflet included in the pack with a medicineIt is written for patients and gives information about taking or using a medicineIt is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

Use this medication regularly to get the most benefit from itTo help you rememberuse it at the same time each dayDo not stop taking this medication without consulting your doctorSome . conditions may become worse when the drug is suddenly stopped.

In selecting a LANOXIN dosing regimenit is important to consider factors that affect digoxin blood levelse.gbody weightagerenal functionconcomitant drugssince toxic levels of digoxin are only slightly higher than therapeutic levelsDosing can be either initiated with a loading dose followed by maintenance dosing if rapid titration is desired or initiated with maintenance dosing without a loading dose.

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the safety and effectiveness of lanoxin in the treatment of heart failure in children have not been established in adequate and well-controlled studies.