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Campo REMoreno JNSuarez Get alEfficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failuresAIDS2003;17(131933-1939.

Indinavir is metabolized by CYP3A4Drugs that induce CYP3A4 activity would be expected to increase the clearance of indinavirresulting in lowered plasma concentrations of indinavirCoadministration of CRIXIVAN and other drugs that inhibit CYP3A4 may decrease the clearance of indinavir and may result in increased plasma concentrations of indinavir.

New onset diabetes mellitusexacerbation of pre-existing diabetes mellitus and hyperglycemia have been reported during post-marketing surveillance in HIV-infected patients receiving protease inhibitor therapySome patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these eventsIn some casesdiabetic ketoacidosis has occurredIn those patients who discontinued protease inhibitor therapyhyperglycemia persisted in some casesBecause these events have been reported voluntarily during clinical practiceestimates of frequency cannot be made and a causal relationship between protease inhibitor therapy and these events has not been established.

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additionally, ponatinib is a p-gp inhibitor and may increase the plasma concentration of a p-gp substrate such as, indinavir.