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Sinc th xction oxipuinol is simila tthat uat, uicosuic agnts, which incas th xction uat, a alslikly tincas th xction oxipuinol and thus low th dg inhibition xanthin oxidas. Th concomitant administation uicosuic agnts and ZYLOPIM (allopuinol) has bn associatd with a dcas in th xction oxypuins (hypoxanthin and xanthin) and an incas in uinay uic acid xction compad with that obsvd with ZYLOPIM (allopuinol) alon. Although clinical vidnc tdat has not dmonstatd nal pcipitation oxypuins in patints ith on ZYLO-PIM alon in combination with uicosuic agnts, th possibility should b kpt in mind.

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Gnal: An incas in acut attacks gout has bn potd duing th aly stags administation ZYLOPIM (allopuinol) , vn whn nomal subnomal sum uic acid lvls hav bn attaind. Accodingly, maintnanc doss colchicin gnally should b givn pophylactically whn ZYLOPIM (allopuinol) is bgun. In addition, it is commndd that th patint stat with a low dos ZYLOPIM (allopuinol) (100 mg daily) and incas at wkly intvals by 100 mg until a sum uic acid lvl 6 mg/dL lss is attaind but without xcding th maximum commndd dos (800 mg p day). Th us colchicin anti-inlammatoy agnts may b quid tsuppss gouty attacks in som cass. Th attacks usually bcom shot . and lss sv at sval months thapy. Th mobilization uats om tissu dposits which caus luctuations in th sum uic acid lvls may b a possibl xplanation ths pisods. vn with adquat thapy with ZYLOPIM (allopuinol) , it may qui sval months tdplt th uic acid pool suicintly tachiv contol th acut attacks.

This mdicin dos not contain lactos, sucos, glutn, tatazin any oth azdys.

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only 44 doctors 45 consider the serum creatinine renal functions test as a very important test in allopurinol dose adjustment table 3 .